Knockout of maternal CD163 protect fetuses from PRRSv infection

Sci Rep. 2017 Oct 17;7(1):13371. doi: 10.1038/s41598-017-13794-2.

Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV).

Prather RS1, Wells KD1, Whitworth KM1, Kerrigan MA2, Samuel MS1, Mileham A3, Popescu LN2, Rowland RRR4.

Author information

1

Division of Animal Science, College of Food Agriculture and Natural Resources, University of Missouri, Columbia, MO, 65211, USA.

2

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA.

3

Genus, plc, DeForest, Wisconsin, USA.

4

Department of Diagnostic Medicine and Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, 66506, USA. browland@vet.k-state.edu.

Abstract

After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include abortion, fetal death and respiratory disease in newborn piglets. CD163 is the receptor for the virus. In this study, CD163-positive fetuses, recovered between 109 days of gestation or 20 days after maternal infection, were completely protected from PRRSV in dams possessing a complete knockout of the CD163 receptor. The results demonstrate a practical means to eliminate PRRSV-associated reproductive disease, a major source of economic hardship to agriculture.

PMID:

 

29042674

 

DOI:

 

10.1038/s41598-017-13794-2